Wednesday, 18 January 2017

Progress with Parkinson's!

A naturally-occurring compound has been found to block the molecular process thought to lie behind Parkinson's Disease and could form the basis of a possible treatment, scientists have said.

The preliminary findings suggest the compound, called squalamine, also suppresses the toxic products associated with the process, researchers at Cambridge University have found.
Academics stressed further research is needed, and that findings are based on cell cultures developed in the lab and testing in nematode worms.

A trial in Parkinson's Disease patients is now being planned by one of the researchers involved in the study

But the compound has been used in clinical trials for cancer and eye conditions in America, and a trial in Parkinson's Disease patients is now being planned by one of the researchers involved in the study.
The study was led by academics from the Centre for Misfolding Diseases based at Cambridge University and Georgetown University and the National Institutes of Health in the United States.

It is not yet clear whether squalamine can reach the specific regions of the brain where the main molecular processes determining Parkinson's Disease take place, or what form any resulting drug might take.
Squalamine is a steroid which was discovered in the 1990s in dogfish sharks, although the form now used by scientists is a safer, synthetic analogue.
To date, it has been extensively investigated as a potential anti-infective and anti-cancer therapy.
In the new study, researchers found squalamine inhibits the early formation of toxic aggregates of the protein alpha-synuclein - a process thought to start a chain reaction of molecular events eventually leading to Parkinson's Disease - and can suppress the toxicity of these poisonous particles.
Co-author Michele Vendruscolo, of Cambridge University, said: "This is an encouraging step forward in our efforts to discover potential drugs against Parkinson's Disease."
Researchers said it would be interesting to investigate the efficacy of squalamine as a means to alleviate certain symptoms, including severe constipation and symptoms concerning the peripheral nervous system.
The findings are published in Proceedings Of The National Academy Of Sciences (PNAS).

2 comments:

  1. At the age of 54 I started experiencing lack of muscle control when performing strenuous exercise. It was very periodic, as I got older, the episodes became more frequent, and I started experiencing voice box spasms, excessive sweating, and trouble swallowing. I also started to have episodes when I wasn't so active. My family doctor wasn't able to diagnose my problem, but I was sent to a neurologist and they diagnosed it as Parkinson's. All medications given were not working i had to look for an alternative treatment. I read in a health forum of a herbal clinic in Johannesburg who has a successful treatment to P.D, i immediately contacted the herbal clinic via their website (www.Healthherbalclinic.weebly.com) and purchased the parkinson's herbal formula. I received the parkinson's herbal treatment via courier and immediately commenced usage, i only used the herbal remedy for 7 weeks all my symptoms were unbelievably reversed, i did another series of test i was confirmed free of parkinson's. Visit (www.healthherbalclinic.weebly.com) or email (healthherbalclinic@gmail.com)

    ReplyDelete
  2. i am from California, i have been surfing from Parkinson's Disease for past 2years now, the experiences was really bad, i was passing through a lot of hard times.. some of my symptoms where anxiety or apathy and fatigue, dizziness, poor balance, one day i was searching through the internet for natural remedies for Parkinson's Disease, i saw several post about this Health Center called "General Health Center" cure for Parkinson's Disease, and some Disease, so i was very convinced and ready to be cured with their natural remedies, so i contacted them and i purchased some set of drugs for cure, after few weeks of usage about 6weeks i was free completely of the symptoms and went for a text and i can say now i am free of Parkinson's Disease totally.... indeed their remedies are supper effective... contact them today on their email: contact them on email:(generalhealthcenter1@gmail.com) OR (generalhealthcenter1@outlook.com) or call or text +18722059342

    ReplyDelete