Some studies show that half of all people who develop mental disorders have their first symptoms by the age of 14
The finding is in a new report by the UN agency.
It has pulled together a wealth of published evidence with direct consultations with 10 to 19-year-olds around the world to assess the health issues that affect them.
Some studies show that half of all people who develop mental disorders have their first symptoms by the age of 14, said the report.
The study looked at a broad range of issues, including tobacco, alcohol and drug use, HIV, injuries, mental health, nutrition, sexual and reproductive health, and violence.
Traffic injuries were the number two cause of illness and disability, behind depression, with boys three times more likely to die than girls.
WHO said it was crucial for countries to reduce the risk by increasing access to reliable and safe public transport, improve road safety regulations such as alcohol and speed limits, establish safe pedestrian areas around schools and graduated licensing schemes where drivers' privileges are phased in over time.
Worldwide, an estimated 1.3 million adolescents died in 2012, it said.
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