Professor Gary Donohoe
The study’s findings, led by NUI Galway Professor Gary Donohoe, have been published in the leading international peer-reviewed journal JAMA Psychiatry
A new study has revealed that genetic variants associated with risk for schizophrenia and other psychotic disorders are also associated with performance on measures of IQ, memory and social cognition. The discovery was made by NUI Galway Professor of Psychology Gary Donohue, in association with colleagues from Trinity College, Dublin and has just been published in leading journal, JAMA psychiatry.
Professor Gary Donohoe said: “These findings support the view that the genetics of schizophrenia and cognition overlap. The findings also raise the possibility that the risk of developing schizophrenia may be identified by changes in cognitive ability; tell-tale signs found in IQ, memory or social intelligence tests. These cognitive deficits often appear before the emergence of clinical symptoms and go on to predict individual levels of disability. Understanding how genetic variants contribute to this aspect of disability, both individually and interaction, is an important step towards understanding the underlying biology and developing better and more personalized treatments.”
Schizophrenia or bipolar disorder affects about one in 50 Irish adults. Treatments are available, but the successful treatment rates vary. It is as yet unknown what causes or triggers schizophrenia. Disability in these disorders is significantly affected by difficulties with a wide range of neuropsychological problems, including general cognitive ability, memory function, and cognitive abilities relevant to engaging and dealing with others.
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