'Heart attack breakthrough' - Research

Scientists have discovered a way to stimulate muscle cell growth in the heart, limiting the damage to this vital organ after a heart attack

Scientists have now found a new way to potentially regenerate the heart after a heart attack by replacing lost muscle cells. According to Professor Richard Harvey from the Victor Chang Cardiac Research Institute, this is an important step forward toward repairing a broken heart.

“Unlike blood, hair or skin cells, which can renew themselves throughout life, cell division in the heart virtually comes to a standstill shortly after birth, which means the heart can’t fully regenerate if it is damaged later in life,” Professor Harvey explained.

“Previous studies have demonstrated that it is possible to coax heart muscle cells to proliferate again, but only at very trivial levels.

“What the research team has been able to do is boost heart muscle cell numbers by as much as 45% after a heart attack. That’s a huge improvement!”

Scientists focused on a signalling system in the heart driven by a hormone called ‘neuregulin’.

By switching the neuregulin pathway to ‘turbo charge’ the researchers found that heart muscle cells continued to divide in a spectacular way in both the adolescent and adult periods.

Stimulating the neuregulin pathway during a heart attack lead to replacement of lost muscle.

The study has been published in Nature Cell Biology. To read more click here

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